Tamiflu Increasingly Under Fire

Monday, August 10th, 2009

The swine flu’s a-coming, it’s a coming! There’s no ignoring it now, not after today’s front-page story, top-of-the-fold and complete with color-coded maps, in the Washington Post. “‘The virus is still around and ready to explode,’ said William Schaffner, an influenza expert at the Vanderbilt University School of Medicine who advises federal health officials. ‘We’re potentially looking at a very big mess.'”

Wow. You may wonder, as I did: “OK, we had swine flu in the spring, and now they say it’s going to come back soon. Where has it been off to in the meantime?” The answer: in the Southern Hemisphere! It’s winter there now, so I guess it has something to do with cold weather – although it has stuck around to an alarming degree nonetheless in the UK. That could be a function of the rather “un-summery” (i.e. cool, cloudy, rainy) summer we’ve mostly had here so far in Northern Europe.

Turning back to the Northern European press – i.e. to something you may not be able to just read yourself – the French-language Belgian paper Le Soir has picked up on those reports that we discussed here earlier about swine-flu cases being discovered that are resistant to Tamiflu. Once again with Le Soir, the article includes a brief mention of how “The Roche laboratory [maker of Tamiflu] had indicated that it expected a 0.5% rate of resistance to its antiviral [drug] according to results from clinical tests,” and that makes me see red. That’s just marketing propaganda; how can they truly know how widespread the resistance to their drug will be through “clinical tests”?

Here’s what Le Soir has that’s new about the swine flu, however (although they tend to call it the “Flu A/H1N1,” which seems standard for French media): the Tamiflu used to combat it also induces undesirable side-effects in children – “important” effects, according to the article, effects “quite a bit more than the preliminary studies done to get the medicine approved allowed us to guess.” This is evident from the unpleasant experiences of pupils at one particular elementary school in England where they all were given Tamiflu after it was found that one of them had returned from a vacation to Mexico with the swine flu virus, and it obviously argues against that kind of preventive prescription of the drug.

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Pill-Popping Flu Invulnerability

Wednesday, August 5th, 2009

Any residence of Texas knows about “The Valley,” even if he or she doesn’t happen to live there. Not really a valley it all, it’s that area down along the Rio Grande that constitutes the border there between the US and Mexico, a handy place for new Mexican immigrants to the US (legal or otherwise) to get their start, but otherwise producing little of note for the world other than folk singer Kris Kristofferson and legends from the Streets of Laredo.

Now The Valley has produced something else, something that has caught the attention of the Pan American Health Organization (PAHO): a new strain of swine flu that is resistant to the main drug the world is relying on to counter its effects, Tamiflu. Reports about this come both from France’s Le Point and (perhaps somewhat strangely) Denmark’s leading business newspaper, Børsen, which cite PAHO spokeswoman Maria Teresa Cerqueira, attending a swine flu conference currently happening in La Jolla, California.

Granted, this same Tamiflu-resistant strain has already been spotted in Denmark, Japan, Hong Kong, and even once before in North America, namely in Canada. But how did it come about? Cerqueira: “In the USA Tamiflu is sold by prescription, but in Mexico and Canada they sell it over-the-counter and take it at the first sneeze. And now that it is really needed, it doesn’t work anymore.” In other words, if you grant the assumption that the swine flu we can expect in the autumn is likely to be deadlier than what we’ve encountered so far (although, to be fair, the past strain did kill 353 persons in the USA and 143 in Mexico, among others), then pill-popping Mexicans and Canadians have exhausted the world’s Tamiflu firepower on the earlier, safer version – which reportedly merely caused symptoms comparable to any common, garden-variety flu – and thus have left everyone vulnerable to the more dangerous strain.

There’s perhaps a glimmer of hope in the Le Point piece, namely that one patient found to have the Tamiflu-resistant virus was able to be cured with another drug, “Zanamivir,” made by GlaxoSmithKline. So maybe there’s still an alternative cure available – until the virus in short order develops resistance to that!

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